Sekyiamah's working practice focuses on the role of women, from the perspective of a young woman living within a West African Society and of the domestic life in which she grew up in, she considers her work to be feminist in its outlook. Her paintings incorporate abstract markings, African textile design motifs, combined with depictions of black women, for example a figure in a bikini or a silhouetted nude form, this challenging the status quo of a male dominated patriarchy.
Sekyiamah is a recipient of the new inaugural Judith Ellen Prize (2022), an annual prize dedicated to supporting emerging women artists within Africa and the diaspora, this also preceded her recent solo exhibition at the Nubuke Foundation in Accra, Ghana. As one of the few emerging abstract-figurative woman artists in Ghana and the continent, Elizabeth acts as a beacon of hope, pushing through and creating. Her existence is the biggest form of rebellion in its entirety.